Enabling Precision Medicine: Decoding the Human Genome with Deep Learning Models
Speaker: Olga Troyanskaya, PhD
A key challenge in medicine and biology is to develop a complete understanding of the genomic architecture of disease. Yet the increasingly wide availability of ‘omics’ and clinical data, including whole genome sequencing, has far outpaced our ability to interpret these sequences. Challenges include interpreting the 98% of the genome that is noncoding to identify variants that are functional and may lead to disease, detangling genomic signals regulating cell-lineage-specific gene expression, and mapping the resulting genetic circuits and networks in disease-relevant cell-types to specific phenotypes and clinical outcomes. I will discuss methods that address these challenges, and highlight their applications to cancer and mental health disorders.
Date: Thursday, October 20, 2022 12:00-1:00 PM HST